Industrial Chemistry
Within the scope of Good Laboratory Practices, testing procedures are required for the licensing of chemical products to be put on the market. Long-term testing procedures are carried out to determine the hazards of chemical products to humans, animals and the environment and to license them.
Depending on the usage areas and conditions of industrial chemical products, testing procedures are carried out within the scope of "Good Laboratory Practices".
Physicochemical Tests
Accurate determination of physical and chemical properties is critical for predicting the behavior, safety and appropriate conditions of use of a substance. Here are some physicochemical tests according to prominent OECD guidelines:
- OECD TG 102 - Melting Point/Melting Range: Determines the temperature range at which a solid substance changes from a solid to a liquid state.
- OECD TG 103 - Boiling Point: Determines the temperature at which the vapor pressure of a substance equals atmospheric pressure.
- OECD TG 109 - Determination of Density: Measures the mass per unit volume of solid and liquid substances.
- OECD TG 114 - Determination of Viscosity: Determines the fluidity of liquids, i.e. their resistance to flow.
- OECD TG 105 - Water Solubility: Determines the extent to which a substance is soluble in water.
- OECD TG 104 - Vapor Pressure: The pressure value that reflects the tendency of a substance to evaporate is measured.
- OECD TG 115 - Surface Tension: Intermolecular interactions are analyzed by determining the surface tension of aqueous solutions.
- OECD TG 122 - pH Determination: Indicates the acidic or basic nature of solutions.
- OECD TG 113 - Explosivity Properties: The potential of a substance to react by violent exothermic reactions is evaluated.
- OECD TG 117 - Oxidizing Properties: The oxidizing effects of solids are tested.
- OECD TG 112 - Thermal Stability: Resistance to high temperatures is measured.
- OECD TG 124 - Reactivity with Water: The capacity of a substance to react with water to produce heat or gas is tested.
In Vivo Tests
These tests on living organisms are used to holistically assess the potential toxic effects of a substance. Here are the featured in vivo testing guidelines:
Acute Toxicity Tests
- OECD TG 420 / 423 - Acute Oral Toxicity: The toxic effects of a single oral dose in a short period of time are examined.
- OECD TG 402 - Acute Dermal Toxicity: The effects of a single dose administered through the skin are evaluated.
- OECD TG 403 - Acute Inhalation Toxicity: Toxic effects of substances ingested by inhalation are observed.
Local Tolerance and Irritation Tests
- OECD TG 404 - Skin Irritation/Corrosion
- OECD TG 405 - Eye Irritation/Corrosion
- OECD TG 406 - Skin Sensitization: The potential of the substances to cause an allergic reaction on the skin after contact is tested.
Repeated Dose Toxicity Studies
- OECD TG 407 / 408 - 28 and 90 Day Oral Toxicity
- OECD TG 410 - 28 Day Dermal Exposure Test
- OECD TG 411 - 28 or 90 Day Inhalation Toxicity
Genotoxicity Tests
- OECD TG 474 - Micronucleus Test
- OECD TG 475 - Chromosomal Aberration Test
- OECD TG 471 - Ames Test (although in vitro, it is considered a complementary test for determining genotoxic risks)
Reproductive and Developmental Toxicity
- OECD TG 414 - Prenatal Development
- OECD TG 415 - Single Generation Reproductive Toxicity
- OECD TG 416 - Two Generation Reproductive Toxicity
"Good Laboratory Practices (GLP)" through our solution partners and foreign partners in accordance with the relevant legal regulations and standards in our laboratories serving in many parts of Turkey It is carried out on pharmaceutical products.
You can contact us for "Good Laboratory Practices (GLP)" in Food and Feed Additives.
