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Adenovirus Type 5 Test in Virucidal Activity Tests: Efficacy and Standards

What are the Characteristics of Adenovirus? What is the Disease It Causes? What are the Ways of Transmission and Prevention?

Adenovirus Type 5 Test in Virucidal Activity Tests: Efficacy and Standards

What is Adenovirus Type 5?

Adenovirus Type 5 (HAdV-5) is a non-enveloped virus that can cause respiratory infections, conjunctivitis and gastrointestinal disorders in humans. Due to its non-enveloped nature, it is more resistant to disinfectants, making it an ideal test organism for antiviral efficacy assessments.

The Adenovirus Type 5 test is an important assay to evaluate the efficacy of disinfectants and biocidal products against non-enveloped viruses. Non-enveloped viruses have a special place in virucidal efficacy testing because they are more resistant to environmental conditions and chemicals. Adenovirus Type 5 is a widely used model organism within this group of viruses.

What is the Importance of the Test?

  1. Efficacy on Non-Enveloped Viruses: Non-enveloped viruses are more resistant to disinfectants than enveloped viruses. This test demonstrates a product's effectiveness in harsh conditions.
  2. Critical to Public Health: Adenoviruses can spread rapidly in public living spaces such as hospitals, schools and sports facilities. It is therefore necessary to prove the efficacy of the biocidal products used.
  3. Regulatory and Market Requirements: International standards and regulations require products to prove efficacy against non-enveloped viruses. Adenovirus Type 5 testing is frequently used to meet these requirements.


What are the Relevant Standards?

EN 14476: This European standard includes protocols for assessing the efficacy of disinfectants and biocidal products against enveloped and non-enveloped viruses. Adenovirus Type 5 is one of the test organisms specified in the non-enveloped virus category of this standard.

2. ASTM E1053: The American standard is used to assess virus inactivation on hard surfaces and supports testing with non-enveloped viruses.

3. ISO 21702: An international standard for the assessment of the activity of viruses on surfaces.


Evaluation Criteria

  • ≥4-logReduction (10,000-fold Reduction): The product is considered very effective.
  • ≥3-logReduction (1,000-fold Reduction): Acceptable level of efficacy.
  • <3-log Reduction: The efficacy of the product is considered insufficient.

Nanolab Laboratories Group continues to provide services within the scope of Virucidal Activity Tests. We also provide services in Medical Device Analysis.

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