Determination of 2-MCPD, 3-MCPD and Glycoside Esters

3-Monochloropropane-1,2-diol (3-MCPD), 2-monochloropropane-1,3-diol (2-MCPD) and glycidol, also known as contaminants in foods, can occur during the refining process of oils and fats at high temperature or in the presence of chloride-containing salts. As a result of studies, the importance of analyzing substances classified as carcinogenic is increasing.

The tolerable daily intake for MCPD-esters is 0.8 µg/kg body weight according to the European Food Safety Authority (EFSA).

There are various analysis methods for the determination of MCPD-esters. In general, they can be analyzed in two groups:
- Direct analysis using LC-MS/MS
- Indirect analysis by GC-MS

3-Monochloropropane-1,2-diol (3-MCPD), 2-monochloropropane-1,3-diol (2-MCPD) and glycidol, which can be found in margarines and vegetable oils as well as in bread, biscuits and malt-based food ingredients, can be analyzed.