Genotoxicity Tests

What are Genotoxicity Tests? On Which Products Is It Performed?

Genotoxicity in general terms; It can be defined as damage to the DNA structure, nucleus and chromosomes.

Within the scope of the said damages;

- Gene mutations
- DNA breaks
- DNA inserts
- Chromosome abnormalities
- Clastogenicity (chromosome aberration or breakage)
- Aneuploid (Numerical changes in a single chromosome)

In Which Areas and On Which Products Are Genotoxicity Tests Performed?

Genotoxicity tests are carried out to determine the damage that may occur in the genetic material directly or indirectly, consisting of in vitro and in vivo tests.

Main purposes of genotoxicity tests:

- Determination of human risk ratio
- Identification of mutagens
- Prevention of exposure

Genotoxicity Test Areas:

- UV and irradiation factors that can affect the genome
- Pesticides
- drug studies
- Food additives
- Nanomaterials

What Are the Tests Performed Under Genotoxicity?

- Salmonella / Microsome Mutagenicity (Ames) Test
- Comet Test
- Chromosome Abnormalities (CA) Test
- Sibling Chromatite Exchange (PPE) Test
- Micronucleus (MN) Test

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