Gluteraldehyde Analysis in Biocidal Products: Efficacy and Safety Assessment

What are the Uses of Glutaraldehyde in Biocidal Products? Harms, Benefits...

What is Gluteraldehyde (C₅H₈O₂)?

Glutaraldehyde, which is used in biocidal products and has an approved sterilization effect, is active in both acid and basic media. Alkaline activated 2% glutaraldehyde solution shows sporocidal effect. Disinfection is achieved by contact of glutaraldehyde for 30-60 minutes and chemical sterilization is achieved by contact for 4-10 hours. The duration of action of alkaline-activated glutaraldehyde is between 14-28 days.

Glutaraldehyde has a strong sterilization effect. However, it is harmful to use more than 2% due to its moderately toxic and irritant effect. For people in the same environment, the environments used with glutaraldehyde should have a good ventilation system. Direct eye contact or inhalation of vapors may have negative consequences. If its residue remains in medical instruments, it may cause tongue swelling and bloody diarrhea in patients. Therefore, if it is used in instruments, it should be washed with distilled water.

Determination of glutaraldehyde in biocidal products is considered an important parameter in order to ensure proper sterilization and to take precautions against these hazards.

Bactericidal, Fungicidal and Virucidal Activity:

Glutaraldehyde kills microorganisms by irreversibly oxidizing their cell walls and protein structure.
It is a broad spectrum disinfectant as it is especially effective on resistant microorganisms.

Application Areas:

Medical device disinfection: It shows effective microorganism destroying properties on devices and equipment.
Water disinfection: It is used to ensure the biological cleanliness and drinkability standards of water.

What are the Analysis Methods?

Titration Method: It is used to react a certain volume of a standard solution with glutaraldehyde solution and determine the amount of the solution at the end of the resulting titration reaction. It is a common method for verifying the concentration of glutaraldehyde in biocidal products.
Spectrophotometric Analysis: The concentration is calculated by measuring the absorbance of the glutaraldehyde solution.
Gas Chromatography (GC): Gluteraldehyde is separated in the gas phase and its concentration is determined.

Nanolab Laboratories Group continues to provide services within the scope of Efficacy Analysis in Biocidal Products. We also provide services in Irritation Analysis.

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