OECD 105: Water Solubility

The solubility of chemicals in water can be greatly affected by the presence of impurities. OECD 105: Water Solubility guideline contains the test method for determining the solubility in water of pure substances that are stable and non-volatile in water. Within the scope of the guide, the test methods of substances with a solubility below or above 102 g/l are as follows:

- Column elution method
- Bottle method

To be tested before testing It may also be necessary to know properties of the sample such as structural formula, vapor pressure, dissociation constant and pH. It also includes a simple preliminary test to determine the time required to reach saturation as well as the approximate appropriate amount of sample before the final test performed at 20 ± 0.5 °C.

OECD 105: Water Solubility